传记
Dr. Taylor is an assistant professor of chemistry and biochemistry. She grew on Lake Michigan in Grand Haven, MI. She participated in Science Olympiad which inspired her to pursue a degree in molecular biology and biochemistry. 在读研究生期间, she found her passion for teaching undergraduates and pursued a graduate teaching certificate. She was awarded a coveted teaching postdoc award that allowed her to teach at Southwestern University, a small liberal arts college in Texas. She was later hired there full time as an assistant professor where she taught general chemistry, biochemisty, physical chemistry and a nonmajors chemistry of food course. She was hired at Carroll in Fall 2020 during the COVID pandemic. She is excited to become a part of the Carroll community and meet more students and faculty after quarantine is ended.
Dr. Taylor loves walking and riding her bike to campus and around 沃基肖. She has a three year old who is growing up to be a big science nerd. She also loves singing in choirs and hopes to continue at Carroll.
专业领域
生物化学, 分子克隆, DNA修复, enzyme mechanism and kinetics, Kintek explorer kinetics computer simulation
Scholarly and Professional Achievements
会谈
2018 American Chemical Society (ACS) National Meeting, Boston, MA
“Teaching principles of chemical equilibria using computer simulation methods”
2015 Enzyme Mechanisms Conference, San Luis Resort, Galveston, TX
“Kinetic mechanism for the flipping and excision of 1,N6-乙丙腺嘌呤
2014 Annual Midwest DNA Repair Meeting, Detroit, MI
“Kinetic mechanism for the excision of εA by AlkA”
出版物
2014年更名
泰勒,E. L.凯萨文，P. M.沃尔夫，A. E.O 'Brien, P. J. (2018) Distinguishing specific and nonspecific complexes of alkyladenine DNA glycosylase, 生物化学(提交).
泰勒,E. L.O 'Brien, P. J. (2015) Kinetic mechanism for the flipping and excision of 1,N6-乙丙腺嘌呤 生物化学54, 898-908.
好,P. D.——肯德尔·A.伊格纳茨-胡佛，J., 米勒,E. L.，派，D. A.里韦拉，S. R.卡里克·B.恩格尔克，D. R. (2013) Silencing near tRNA genes is nucleosome-mediated and distinct from boundary element function. 526年基因, 7-15.
Pratt-Hyatt, M.，派，D. A.豪斯勒，R. A.沃兹尼亚克，G. G.很好，P. D., 米勒,E. L.麦克劳德，我. X.叶茨，J. R. 3rd霍珀，A. K.恩格尔克，D. R. (2013) Mod5 protein binds to tRNA gene complexes and affects local transcriptional silencing. PNAS上110, E3081-9.
巴塞洛缪,年代. R.贝尔，E. H.萨默菲尔德，T.纽曼，L。. C., 米勒,E. L.帕特森，B.，尼迪，Z. P.W .阿克曼. E. 第四名，J .坦西. T. (2012) Distinct cellular pools of perilipin 5 point to roles in lipid trafficking. 生物化学，生物物理学报，1821, 268-278.
What should students know about you?
泰勒研究实验室
土壤和肠道细菌 枯草芽孢杆菌, is constantly being exposed to damaging chemicals. These chemicals damage DNA in a variety of ways, including adding alkyl groups to the bases and DNA backbone. As even the simplest methyl group can inhibit replication machinery, or cause mutations in the genome, it is imperative that cells evolve pathways to protect themselves from such damage. Bacterial cells that are exposed to low doses of DNA damaging chemicals “adapt” to withstand higher doses of the same chemicals. This “adaptive response” upregulates the expression of alkylation repair enzymes such as glycosylases that remove a damaged base from the genome.
有趣的是, 枯草芽孢杆菌 contains genes for at least four glycosylases that repair alkylation damage, including one that is typically only found in eukaryotes. Little is known about these enzymes and their overall role in alkylation repair and the adaptive response in B. 细小. The Taylor lab uses various molecular biology and biochemistry techniques to characterize these enzymes. By deleting these various genes from the genome and exposing cells to damaging chemicals, we hope to comprehend the complicated nature of DNA damage repair in bacteria. By purifying the proteins and reacting them with damaged DNA in kinetics assays, we hope to characterize their mechanisms and determine their substrate specificity.